A Lorelei Verthandi

Curriculum Vitae in the Sciences

Lorelei holds a lifelong passion for science and understanding reality, and especially loves sharing what she learns with others. Professionally, she has had the privilege of contributing her skills toward developing new treatments for some of humanity’s worst diseases.

Education and Experience

  • Dartmouth College, 2003-2007. Bachelor of Arts, Major in Biology (Neurobiology, Genetics, and Development), Minor in Physics.
  • Broad Institute, 2007-2020. Research Associate I-II, Microbial Genetics Group. Explored new treatments and mechanisms of action for infectious diseases: primarily Mycobacterium tuberculosis, but also Pseudomonas aeruginosa and the SARS-CoV-2 virus.
  • Remix Therapeutics, 2022-current. Senior Research Associate I-II, Biological Sciences and Lead Development. Investigating gene targets and developing drug candidates to treat diseases like cancer via modulation of RNA splicing.

Publications

  • B Poulsen et al [incl. A Golas]. (2025 Feb) “Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen.” Cell Chem Biol. 32(2):307-324.e15. doi: 10.1016/j.chembiol.2024.12.001.
  • S Zhang et al [incl. A Golas]. (2023 Apr) “High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020.” mBio. 14(2):e03523-22. doi: 10.1128/mbio.03523-22.
  • E Johnson et al [incl. A Golas]. (2019 Jul) “Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.” Nature. 571(7763):72-78. doi: 10.1038/s41586-019-1315-z.
  • A Barczak et al [incl. A Golas]. (2017 May) “Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence.” PLoS Pathog. 13(5):e1006363. doi: 10.1371/journal.ppat.1006363.
  • S Grant et al [incl. A Golas]. (2013 Oct) “Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model.” ACS Chem Biol. 8(10):2224-34. doi: 10.1021/cb4004817.
  • S Stanley et al [incl. A Golas]. (2012 Aug) “Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.” ACS Chem Biol. 7(8):1377-84. doi: 10.1021/cb300151m.
  • N Chand et al [incl. A Golas]. (2011 Jun) “The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.” J Bacteriol. 193(12):2989-99. doi: 10.1128/JB.01546-10.